Academic Cancer Center Phase I Program Development

Academic Cancer Center Phase I Program Development

Multiple factors critical to the effectiveness of academic phase I cancer programs were assessed among 16 academic centers in the U.S. Successful cancer centers were defined as having broad phase I and I/II clinical trial portfolios, multiple investigator-initiated studies, and correlative science. The most significant elements were institutional philanthropic support, experienced clinical rese...

Personalized medicine in a phase I clinical trials program: The M. D. Anderson Cancer Center Initiative.

CRA2500 The full, final text of this abstract will be available in Part II of the 2011 Annual Meeting Proceedings, distributed onsite at the Meeting on June 4, 2011, and as a supplement to the June 20, 2011, issue of Journal of Clinical Oncology.

Systematic Program Development Academic Staff

Evaluating the Implementation of Child Development and Care Program in Isfahan Comprehensive Child Development Center

Abstract Background: The Comprehensive Child Development Center was established in 2012 in the center of Isfahan province to rapidly identify and intervene in the developmental problems of children. The aim of this study was to evaluate the implementation of this program. Methods: This was a descriptive-analytical study conducted based on the framework for evaluating public health programs es...

Electrocardiograms (ECGs) in phase I anticancer drug development: the MD Anderson Cancer Center experience with 8518 ECGs.

BACKGROUND Cardiac sequelae from oncologic drugs are important in early cancer drug development. Prolongation of the corrected QT interval (QTc) by noncardiac drugs is the most common cause of drug development delays, nonapprovals and postmarketing withdrawals by the US Food and Drug Administration. PATIENTS AND METHODS We analyzed 8518 electrocardiograms (ECGs) in 525 consecutive cancer pati...